Bioactive Small Molecules
Cayman Chemical ArachIdonyl ChlorIde 5mg
A derivative of arachidonic acid; has been used as an intermediate in the synthesis of arachidonic acid derivatives
Medchemexpress LLC Perfluorobutylsulfonyl fluoride | 375-72-4 | 99.9% | 302.09 | 50 G
Perfluorobutylsulfonyl fluoride is a biological molecule. It is intended for research use only and not for sale to patients. This product is a liquid with a density of 1.774±0.06 g/cm3 and appears colorless to light yellow.
- Shipping at room temperature in continental US; may vary elsewhere
- Storage of pure form at -20°C for 3 years, 4°C for 2 years
- Storage in solvent at -80°C for 6 months, -20°C for 1 month
Cayman Chemical ANTIBODY ICAAc 25mg
A solvatochromic fluorescent pH probe; ex/em = 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively; abs/em = 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous buffer, with fluorescence intensity increasing as pH decreases; can be used for live cell applications
Abcam SM64, beta1 adrenoceptor antagonist, 50MG
MW 459.54 g/mol, Purity >97%. Highly selective β₁ adrenoceptor antagonist (log KD = -7.5 for β₁ and incomplete binding inhibition for β₂). Exhibits β₁-partial agonist activity (log EC₅₀ = -8; 34% isoprenalinie maximum). Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Hydroxytyrosol acetate | 69039-02-7 | 1 ML
Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with diverse effects, including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. It functions as a prodrug for Hydroxytyrosol, being converted to its active form in vivo. This compound is extensively used in scientific research concerning *Vibrio* infection, arterial thrombosis, Alzheimer's disease, and other related fields.
- Inhibits the growth of *Vibrio* bacteria by increasing membrane permeability and interacting with DNA.
- Reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production.
- Alleviates neuronal apoptosis and inflammatory responses by up-regulating ERβ expression.
- Improves cognitive function in Alzheimer's disease models.
- Shows time-dependent DPPH radical scavenging activity.
Medchemexpress LLC 3-(glycidyloxy)propyltrimethoxysilane | 2530-83-8 | MFCD00005144 | 99.4% | 236.34 | C9H20O5Si | 100 G
3-Glycidyloxypropyltrimethoxysilane is an epoxy-functional organosilane used to introduce glycidoxy groups onto surfaces and polymer matrices for improved adhesion, crosslinking, and surface modification.
- Epoxy-functional silane coupling agent suitable for surface modification and adhesion promotion.
- Used as a crosslinking and adhesion promoter in coatings, composites, and sol-gel systems.
- Compatible with inorganic substrates and organic polymers to improve interfacial bonding.
- High purity suitable for research and formulation (purity: 99.4%).
- Available in multiple packaging sizes for lab-scale and larger syntheses.
Cayman Chemical ANTIBODY ColumbIn 5mg
A diterpenoid furanolactone with diverse biological activities; inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice (25 mg/kg per day for 3 days); selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM, respectively); reduces carrageenan-induced paw edema in rats; reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis (4, 20, and 100 ppm, dietary); reduces urethane and reduces sleeping time induced by a mixture of urethane and α-choralose but prolongs hexobarbital-induced sleeping time in mice
Cayman Chemical ANTIBODY ZIbotentn 1mg
A selective ETA receptor antagonist (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively); inhibits ET-1-induced growth of HEY, OVCA 433, SKOV3, and A2780 cells in vitro; reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2 in HEY cells; reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner (10-50 mg/kg per day)
Cayman Chemical ANTIBODY FAUC-365 1mg
A dopamine D3 receptor antagonist (Ki = 0.5 nM); selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 µM, respectively) as well as 5-HT1A and 5-HT2 receptors (Kis = 0.36 and 2 µM, respectively); prevents memory impairment in the novel object recognition test in DAT-KD mice when administered prior to object learning from 1-10 mg/kg
Medchemexpress LLC GSK2837808A | 1445879-21-9 | MFCD28133406 | 10 mM * 1 mL in DMSO
GSK2837808A | Putity: >99.0% | MW: 649.62 | 1445879-21-9 | MFCD28133406 | 10 mM * 1 mL in DMSO
Cayman Chemical ANTIBODY PS-10 5mg
A PDHK inhibitor (IC50s = 2.07, 0.8, 21.3, and 0.77 µM for PDHK1, -2, -3, and -4, respectively); selectively binds to PDHK2 over Hsp90 (Kds = 0.239 and 47 µM, respectively); increases heart, liver, and kidney pyruvate dehydrogenase complex activity, decreases blood glucose levels in a glucose tolerance test, and reduces plasma lactate, cholesterol, and triglyceride levels, fat mass, and hepatic lipid accumulation in a mouse model of high-fat diet-induced obesity at 70 mg/kg
Medchemexpress LLC Tempo | 2564-83-2 | MFCD00009599 | 156.25 | 50 G
Tempo is a nitric oxide radical and a selective scavenger of reactive oxygen species (ROS) in mitochondria. It functions as an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. It exhibits mutagenic and antioxidant effects, and can induce DNA strand breaks, as well as exerting cytotoxic and mutagenic properties in mouse lymphoma cells.
- Acts as a nitric oxide radical
- Functions as a selective scavenger of reactive oxygen species (ROS) in mitochondria
- Serves as an organocatalyst, disproportionating superoxide
- Oxidizes primary alcohols to aldehydes in a catalytic cycle
- Exhibits mutagenic and antioxidant effects
- Induces DNA strand breaks
- Exerts cytotoxic and mutagenic properties in mouse lymphoma cells
Medchemexpress LLC Gelsemine | 509-15-9 | 322.40 | 25 MG
Gelsemine is an alkaloid derived from the Chinese herb *Gelsemium elegans*. It has been shown to be effective in mitigating chronic pain and exhibits antinociceptive effects. This compound is an effective agent for the treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. It has demonstrated analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia, increasing mechanical threshold and prolonging thermal latencies.
- Alkaloid sourced from *Gelsemium elegans*.
- Mitigates chronic pain.
- Exhibits antinociceptive effects.
- Treats neuropathic pain.
- Treats sleep disturbance (in PSNL mice).
- Increases non-rapid eye movement (NREM) sleep.
- Decreases wakefulness.
- Decreases c-Fos expression.
- For research use only.
Cayman Chemical ANTIBODY11 12-EET 500UG
A racemic version of a CYP450 metabolite of arachidonic acid; produced as two R/S enantiomers; plays a role in the recovery of depleted calcium pools in cultured smooth muscle cells; inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct (100 nM); increases isolated peripheral blood leukocyte adhesion (50 UG/kg per day)
Cayman Chemical ANTIBODY G10 5mg
An indirect activator of STING signaling; induces IRF3- and IFN-dependent transcription in human fibroblasts, PBMCs, and HUMECs; prevents replication of chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively); increases phosphorylation of IRF3 when used at a concentration of 100 µM but not in cells lacking STING